KEY PUBLICATIONS


Bajic, G, Harrison, S.C. Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses Affiliations. ACS Infectious Diseases 2020 Dec 4; doi:10.1021/acsinfecdis.0c00726 PMID: 33274930  PMCID

Bajic G, Maron MJ, Caradonna TM, Tian M, Mermelstein A, Fera D, Kelsoe G, Kuraoka M, Schmidt AG. Structure-Guided Molecular Grafting of a Complex Broadly Neutralizing Viral Epitope. ACS Infectious Diseases 2020 Apr 20. DOI: 10.1021/acsinfecdis.0c00008 PMID: 32267676

Watanabe, A., McCarthy, K.R., Kuraoka, M., Schmidt, A.G., Adachi, Y., Onodera, T., Tonouchi, K., Caradonna, T.M., Bajic, G., Song, S., McGee, C.E., Sempowski, G.D., Feng, F., Urick, P., Kepler, T.B., Takahashi, Y., Harrison, S.C., Kelsoe, G.  Antibodies to a conserved influenza head interface epitope protect by an IgG subtype-dependent mechanism.  Cell 177:1124-1135 (2019)  PMCID: PMC6825805

Bajic, G., Maron, M.J., Adachi, Y., Onodera, T., McCarthy, K.R., McGee, C.E., Sempowski, G.D., Takahashi, Y., Kelsoe, G., Kuraoka, M., Schmidt, A.G.  Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.  Cell Host Microbe 25:1- 9 (2019) PMID: PMC6401307

McCarthy, K.R., Raymond, D.D., Do, K.T., Schmidt, A.G., Harrison, S.C.  Affinity maturation in a human humoral response to influenza hemagglutinin.  Proc. Natl. Acad. Sci. USA 116 (52):26745-51 (2019)  PMCID: 6936356

Bajic G, van der Poel CE, Kuraoka M, Schmidt AG, Carroll MC, Kelsoe G, Harrison SC. Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies. Scientific Reports. 3492 (2019). doi: 10.1038/s41598-019-40175-8. PMCID: PMC6401307

Lee J, Paparoditis P, Horton AP, Frühwirth A, McDaniel JR, Jung J, Boutz DR, Hussein DA, Tanno Y, Pappas L, Ippolito GC, Corti D, Lanzavecchia A, Georgiou G. Persistent antibody clonotypes dominate the serum Response to influenza over multiple years and repeated vaccinations. Cell Host Microbe 367-376.e5 (2019) doi: 10.1016/j.chom.2019.01.010. PMCID: PMC6417944

Finney J, Watanabe A, Kelsoe G, Kuraoka M. Minding the gap: the impact of B-cell tolerance on the microbial antibody repertoire. Immunol Rev. 2019 November; 292(1): 24–36. doi:10.1111/imr.12805 PMCID:PMC6935408

McCarthy, K.R., Watanabe, A., Kuraoka, M., Do., K.T., McGee, C.E., Sempowski, G.D., Kepler, T.B., Schmidt, A.G., Kelsoe, G., Harrison,S.C. Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.  Immunity 48: 174-184 (2018).  PMCID:  PMC5177464

Raymond, D.D., Bajic, G., Ferdman, J., Suphaphiphat, P., Settembre, E., Moody, M.A., Schmidt, A.G., Harrison, S.C. Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. PNAS 115: 168-173 (2018). PMCID:  PMC5776812

Ferdman, J., Palladino, G., Liao, H-X., Moody, M.A., Kepler, T.B., Del Giudice, G., Dormitzer, P.R., Harrison, S.C., Settembre, E.C., Suphaphiphat, P., Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59-adjuvanted pandemic 2009 H1N1 vaccine. J. Vaccine 10.1016: 8 (2018). PMCID:  PMC6521956

Liu, Y.,  Pan, J.,  Jenni, S.,  Raymond, D.D., Caradonna, T., Do, K.T., Schmidt, A.G., Harrison, S.C., Grigorieff, N.,  CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface.  J. Mol. Biol. 429:18291839 (2017).  PMCID:  PMC5535819

Kuraoka, M., Schmidt A.G., Nojima T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S.C., Kepler T.B., and Kelsoe G.  B-cell selection in germinal centers elicited by complex antigens.  Immunity, 44, 43-54 (2016). PMCID: PMC4794380

Raymond, D.D., Stewart, S.M., Lee, J., Ferdman, J., Bajic, G., Do, K.T., Ernandes, M.J., Suphaphiphat, P., Settembre, E., Dormitzer, P.R., Del Giudice.G., Finco, O., Kang, T.H., Ippolito, G.C., Georgiou, G., Kepler, T.P., Haynes, B.F., Moody, M.A., Liao, H-X., Schmidt, A.G., Harrison, S.C. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nature Medicine 10.1038: 1-7 (2016). PMCID: PMC5485662

Lee J., Boutz, D.R., Chromikova, V., Joyce, M.G., Vollmers, C., Leung, K., Horton, A.P., DeKosky, B.J., Lee, C.H., Lavinder, J.J., Murrin, E.M., Chrysostomou, C., Hoi, K.H., Tsybovsky, Y., Thomas, P.V., Druz, A., Zhang, B., Zhang, Y., Wang, L., Kong, W.P., Park, D., Popova, L.I., Dekker, C.L., Davis, M.M., Carter, C.E., Ross, T.M., Ellington, A.D., Wilson, P.C., Marcotte, E.M., Mascola, J.R., Ippolito, G.C., Krammer, F., Quake, S.R., Kwong, P.D., Georgiou, G.  Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.  Nat Med. 22:1456-1464 (2016). doi: 10.1038/nm.4224. PMCID: PMC5301914.

Schmidt, A.G., Therkelsen, M.D., Stewart, S., Kepler, T.B., Liao, X-H., Moody, M.A., Haynes, B.F., Harrison, S.C.  Viral Receptor-Binding Site Antibodies with Diverse Germline Origins.  <strong>Cell</strong> 161:  1026-1034 (2015)  PMCID:  PMC4441819.

Schmidt, A.G., Do, T.K., McCarthy, K.R., Kepler, T.B., Liao, H-X., Moody, M.A., Haynes, B.F., Harrison, S.C.,  Immunogenic stimulus for germline precursors of influenza-specific antibodies. Cell Reports 13: 2842-50 (2015). PMCID:  PMC4698027.
 
Xu, H., Schmidt, A.G., O’Donnell, T., Therkelsen, M.D., Kepler, T.B., Moody, M.A., Haynes, B.F., Liao, H-X., Harrison, S.C., Shaw, D.E.  Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.  Proteins 83: 771–780 (2015). PMCID: PMC4368477
 
Jackson, K.J.L., Liu, Y., Roskin, K.M., Glanville, J., Hoh, R.A., Seo, K., Marshall, E.L., Gurley, T.C., Moody, M.A., Haynes, B.F., Walter, E.B., Liao, H-X., Albrecht, R.A., García-Sastre, A., Chaparro-Riggers, J., Rajpal, A., Pons, J., Simen, B.B., Hanczaruk, B., Dekker, C.L., Laserson, J.,  Koller, D., Davis, M.M., Fire, A.Z., Boyd, S.D.  Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements.  Cell Host Microbe 16: 105–114 (2014). PMCID: PMC4158033

Schmidt, A.G., Xu, H., Khan, A.R., O’Donnell, T., Khurana, S., King, L.R., Manischewitz, J., Golding, H., Suphaphiphat, P., Carfi, A., Settembre, E.C., Dormitzer, P.R., Kepler, T.B., Zhang, R., Moody, M.A., Haynes, B.F., Liao, H-X., Shaw, D.E., Harrison, S.C.  Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.  Proc Natl Acad Sci USA 110: 264–269 (2013). PMCID: PMC3538208


Whittle, J.R.R., Zhang, R., Khurana, S., King, L.R., Manischewitz, J., Golding, H., Dormitzer, P.R., Haynes, B.F., Walter, E.B., Moody, M.A.,  Kepler, T.B., Liao, H-X.,  Harrison, S.C. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proc Natl Acad Sci USA 108: 14216–14221 (2011). PMCID: PMC3161572

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