Bajic, G, Harrison, S.C. Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses Affiliations. ACS Infectious Diseases, 2020 Dec 4; DOI: 10.1021/acsinfecdis.0c00726 PMID: 33274930

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Finney J, Watanabe A, Kelsoe G, Kuraoka M. Minding the gap: the impact of B-cell tolerance on the microbial antibody repertoire. Immunol Rev. 2019 November; 292(1): 24–36. doi:10.1111/imr.12805

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​​Lee J, Paparoditis P, Horton AP, Frühwirth A, McDaniel JR, Jung J, Boutz DR, Hussein DA, Tanno Y, Pappas L, Ippolito GC, Corti D, Lanzavecchia A, Georgiou G. Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations. Cell Host Microbe. 2019 Mar 13;25(3):367-376.e5. doi: 10.1016/j.chom.2019.01.010

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Bajic G, Maron MJ, Caradonna TM, Tian M, Mermelstein A, Fera D, Kelsoe G, Kuraoka M, Schmidt AG. Structure-Guided Molecular Grafting of a Complex Broadly Neutralizing Viral Epitope. ACS Infectious Diseases . 2020 Apr 20. DOI: 10.1021/acsinfecdis.0c00008 PMID: 32267676

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Lee J, Paparoditis P, Horton AP, Frühwirth A, McDaniel JR, Jung J, Boutz DR, Hussein DA, Tanno Y, Pappas L, Ippolito GC, Corti D, Lanzavecchia A, Georgiou G. Persistent antibody clonotypes dominate the serum Response to influenza over multiple years and repeated vaccinations. Cell Host Microbe. 2019 Mar 13;25(3):367-376.e5. doi: 10.1016/j.chom.2019.01.010. Epub 2019 Feb 19 (2019) PMCID: PMC6417944

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McCarthy, K.R., Raymond, D.D., Do, K.T., Schmidt, A.G., Harrison, S.C.  Affinity maturation in a human humoral response to influenza hemagglutinin.  PNAS 116 (52):  26745-51 (2019)

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Bajic, G., Maron, M.J., Adachi, Y., Onodera, T., McCarthy, K.R., McGee, C.E., Sempowski, G.D., Takahashi, Y., Kelsoe, G., Kuraoka, M., Schmidt, A.G.  Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.  Cell Host & Microbe. May 14; 25:  1- 9 (2019) PMID: PMC6401307

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Watanabe, A., McCarthy, K.R., Kuraoka, M., Schmidt, A.G., Adachi, Y., Onodera, T., Tonouchi, K., Caradonna, T.M., Bajic, G., Song, S., McGee, C.E., Sempowski, G.D., Feng, F., Urick, P., Kepler, T.B., Takahashi, Y., Harrison, S.C., Kelsoe, G.  Antibodies to a conserved influenza head iterface epitope protect by an IgG subtype-dependent mechanism.  Cell 177:  1124-1135 (2019)

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Bajic G, van der Poel CE, Kuraoka M, Schmidt AG, Carroll MC, Kelsoe G, Harrison SC. Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies. Scientific Reports. 2019 Mar 5;9(1):3492. doi: 10.1038/s41598-019-40175-8. PMID: 30837606 

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Ferdman, J., Palladino, G., Liao, H-X., Moody, M.A., Kepler, T.B., Del Giudice, G., Dormitzer, P.R., Harrison, S.C., Settembre, E.C., Suphaphiphat, P., Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59-adjuvanted pandemic 2009 H1N1 vaccine. J. Vaccine 10.1016: 8 (2018).

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Whittle, J.R.R., Zhang, R., Khurana, S., King, L.R., Manischewitz, J., Golding, H., Dormitzer, P.R., Haynes, B.F., Walter, E.B., Moody, M.A.,  Kepler, T.B., Liao, H-X.,  Harrison, S.C. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proc Natl Acad Sci U S A.  August 23; 108(34): 14216–14221 (2011). PMCID: PMC3161572

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Schmidt, A.G., Xu, H., Khan, A.R., O’Donnell, T., Khurana, S., King, L.R., Manischewitz, J., Golding, H., Suphaphiphat, P., Carfi, A., Settembre, E.C., Dormitzer, P.R., Kepler, T.B., Zhang, R., Moody, M.A., Haynes, B.F., Liao, H-X., Shaw, D.E., Harrison, S.C.  Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.  Proc Natl Acad Sci U S A.  110(1): 264–269 (2013). PMCID: PMC3538208

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Xu, H., Schmidt, A.G., O’Donnell, T., Therkelsen, M.D., Kepler, T.B., Moody, M.A., Haynes, B.F., Liao, H-X., Harrison, S.C., Shaw, D.E.  Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.  Proteins  83(4): 771–780 (2015). PMCID: PMC4368477

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Jackson, K.J.L., Liu, Y., Roskin, K.M., Glanville, J., Hoh, R.A., Seo, K., Marshall, E.L., Gurley, T.C., Moody, M.A., Haynes, B.F., Walter, E.B., Liao, H-X., Albrecht, R.A., García-Sastre, A., Chaparro-Riggers, J., Rajpal, A., Pons, J., Simen, B.B., Hanczaruk, B., Dekker, C.L., Laserson, J.,  Koller, D., Davis, M.M., Fire, A.Z., Boyd, S.D.  Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements.  Cell Host Microbe 16(1): 105–114 (2014). PMCID: PMC4158033

 

Schmidt, A.G., Therkelsen, M.D., Stewart, S., Kepler, T.B., Liao, X-H., Moody, M.A., Haynes, B.F., Harrison, S.C.  Viral Receptor-Binding Site Antibodies with Diverse Germline Origins.  Cell 161:  1026-1034 (2015)  PMCID:  PMC4441819.

 

Schmidt, A.G., Do, T.K., McCarthy, K.R., Kepler, T.B., Liao,H-X., Moody, M.A., Haynes, B.F., Harrison,S.C.,  Immunogenic stimulus for germline precursors of influenza-specific antibodies. Cell Reports 9(2015) 13:  2842-50 PMCID:  PMC4698027.

 

Kuraoka, M., Schmidt A.G., Nojima T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S.C., Kepler T.B., and Kelsoe G.  B-cell selection in germinal centers elicited by complex antigens. Immunity, 44, 43-54 (2016). PMCID: PMC4794380

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Raymond, D.D., Stewart, S.M., Lee, J., Ferdman, J., Bajic, G., Do, K.T., Ernandes, M.J., Suphaphiphat, P., Settembre, E., Dormitzer, P.R., Del Giudice.G., Finco, O., Kang, T.H., Ippolito, G.C., Georgiou, G., Kepler, T.P., Haynes, B.F., Moody, M.A., Liao, H-X., Schmidt, A.G., Harrison, S.C. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nature Medicine 10.1038: 1-7 (2016). PMCID: PMC5485662
 

Liu, Y.,  Pan, J.,  Jenni, S.,  Raymond, D.D., Caradonna, T., Do, K.T., Schmidt, A.G., Harrison, S.C., Grigorieff, N.,  CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface.  Journal of Molecular Biology 429:  1829-1839  (2017).  PMCID:  PMC5535819

 

Lee J., Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, Murrin EM, Chrysostomou C, Hoi KH, Tsybovsky Y, Thomas PV, Druz A, Zhang B, Zhang Y, Wang L, Kong WP, Park D, Popova LI, Dekker CL, Davis MM, Carter CE, Ross TM,Ellington AD, Wilson PC, Marcotte EM, Mascola JR, Ippolito GC, Krammer F, Quake SR, Kwong PD, Georgiou G..  Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.  Nat Med. Dec;22(12):1456-1464. doi: 10.1038/nm.4224. Epub 2016 Nov 7. (2016) PMCID: PMC5301914.
 

Raymond, D.D., Bajic, G., Ferdman, J., Suphaphiphat, P., Settembre, E., Moody, M.A., Schmidt, A.G., Harrison, S.C. Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. PNAS 115: 168-173 (2018). PMCID:  PMC5776812

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McCarthy, K.R., Watanabe, A., Kuraoka, M., Do., K.T., McGee, C.E., Sempowski, G.D., Kepler, T.B., Schmidt, A.G., Kelsoe, G., Harrison,S.C. Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity 48: 174-184 (2018).  PMCID:  PMC5177464