2023

           Finney, J., Moseman, A.P., Kong, S., Watanabe, A., Song, S., Walsh, Jr., R.M., Kuraoka, M., Kotaki, R., Moseman, E.A., McCarthy, K.R., Liao, D., Liang, X., Nie, X., Lavidor, O., Abbott, R., Harrison, S.C., Kelsoe, G. Protective human antibodies against a conserved epitope

in pre-and postfusion influenza hemagglutinin PNAS Vol 1, No. 1 e2316964120 PMCID: PMC10769852.

           Yang, L., Caradonna, T.M., Schmidt, A.G., Chakraborty, A.K. Mechanisms that promote the evolution of cross-reactive antibodies upon vaccination with designed influenza immunogens. Cell Reports 42, 112160 PMID: 36867533 PMCID: PMC10184763.

           Sawant, S., Gurley, S.A., Overman, R.G., Sharak, A., Mudrak, S.V., Oguinn III, T., Sempowski, G.D., Sarzotti-Kelsoe, M., Walter, E.B., Xie, H., Pasetti, M., Moody, A.M., Tomaras, G.T.H3N2 influenza hemagglutinination inhibition method qualification with data driven statistical methods for human clinical trials. Frontiers in Immunology 10.3389/fimmu PMID: 37090729; PMCID: PMC10117676.

           Phillips AM, Maurer DP, Brooks C, Dupic T, Schmidt AG, Desai MM. Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody. eLife 2022, 12:383628. PMCID: PMC9995116.

           Yang L, Caradonna TM, Schmidt AG, Chakraborty AK. Mechanisms that promote the evolution of cross-reactive antibodies upon vaccination with designed influenza immunogens. Cell Reports 2023, 42:112160. PMID: 36867533 PMCID: PMC10184763.

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2022

           Caradonna TM, Ronsard L, Yousif AS, Windsor IW, Hecht R, Bracamonte-Moreno T, Roffler A, Maron MJ, Maurer DP, Feldman J, Marchiori E, Barnes R, Rohrer D, Lonberg N, Oguin TH, Sempowski, GD, Kepler, TB, Kuraoka M, Lingwood D, Schmidt AG. An epitope-enriched immunogen expands responses to a conserved viral site.  Cell Reports 2022, 41:111628.  PMCID: PMC9883670.

​           Kuraoka, M., Curtis, N.C., Watanabe, A., Tanno, H., Shin, S., Ye, K., Macdonald, E., Lavidor, O., Kong, S., Von Holle, T., Windsor, I., Ippolito, G., Georgiou, G., Walter, E.B., Kelsoe, G., Harrison, S.C., Moody, M.A., Bajic, G., Lee, J. Infant Antibody Repertoires during the First Two Years of Influenza Vaccination mBio 13 (6) PMCID: PMC9765176.

           Kuraoka, M, Yeh, C-H, Bajic G, Kotari R, Song S, Windsor I., Harrison SC, Kelsoe G.  Recall of B cell memory depends on relative locations of prime and boost immunization.  Sci Immunol 2022; 7:eabn5311. PMCID: PMC9169233.

​           Yeh CH, Finney J, Okada T, Kurosaki T, Kelsoe G. Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells. Immunity 2022; 55:272-279.e7. PMCID: PMC8842852.

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2021

            Caradonna, TM, Schmidt, AG. Protein engineering strategies for rational immunogen design.  NPJ Vaccines 2021; 6:154. PMCID: PMC8683408.

            Song S, Manook M, Kwun J, Jackson AM, Knechtle SJ, Kelsoe G. A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines. Commun Biol. 2021;4:1338. PMCID: PMC8617053.

            Bajic G, Harrison SC. Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses. ACS Infect Dis. 2021;7:1-5. PMCID: PMC8276581.

            McCarthy KR, Lee J, Watanabe A, Kuraoka M, Robinson-McCarthy LR, Georgiou G, Kelsoe G, Harrison SC. A prevalent focused human antibody response to the influenza hemagglutinin head interface. mBio. 2021;12:e0114421. PMCID: PMC8262862.

            McCarthy KR, Von Holle TA, Sutherland LL, Oguin TH, III, Sempowski GD, Harrison SC, Moody MA. Differential immune imprinting by influenza virus vaccination and infection in non-human primates. Proc Natl Acad Sci U S A. 2021;118:e2026752118. PMCID: PMC8201799.

 

2020

            Bajic G, Maron MJ, Caradonna TM, Tian M, Mermelstein A, Fera D, Kelsoe G, Kuraoka M, Schmidt AG. Structure-Guided Molecular Grafting of a Complex Broadly Neutralizing Viral Epitope. ACS Infect Dis. 2020;6:1182-91. PMCID: PMC7291361.

 

2019

            McCarthy KR, Raymond DD, Do KT, Schmidt AG, Harrison SC. Affinity maturation in a human humoral response to influenza hemagglutinin. Proc Natl Acad Sci U S A. 2019.; 116:26745-26751. PMCID: PMC6936356.

            Finney J, Watanabe A, Kelsoe G, Kuraoka M. Minding the gap: The impact of B-cell tolerance on the microbial antibody repertoire. Immunol Rev. 2019;292:24-36. PMCID: PMC6935408.

            Onodera T, Hashi K, Shukla RK, Miki M, Takai-Todaka R, Fujimoto A, Kuraoka M, Miyoshi T, Kobayashi K, Hasegawa H, Ato M, Kelsoe G, Katayama K, Takahashi Y. Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses. J Immunol. 2019;203:3282-92. EPMCID: PMC6900486.

            Watanabe A, McCarthy KR, Kuraoka M, Schmidt AG, Adachi Y, Onodera T, Tonouchi K, Caradonna TM, Bajic G, Song S, McGee CE, Sempowski GD, Feng F, Urick P, Kepler TB, Takahashi Y, Harrison SC, Kelsoe G. Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism. Cell. 2019;177:1124-35. PMCID: PMC6825805.

            Bajic G, Maron MJ, Adachi Y, Onodera T, McCarthy KR, McGee CE, Sempowski GD, Takahashi Y, Kelsoe G, Kuraoka M, Schmidt AG. Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope. Cell Host Microbe. 2019;25:827-385. PMCID: PMC6748655

            Adachi Y, Tonouchi K, Nithichanon A, Kuraoka M, Watanabe A, Shinnakasu R, Asanuma H, Ainai A, Ohmi Y, Yamamoto T, Ishii KJ, Hasegawa H, Takeyama H, Lertmemongkolchai G, Kurosaki T, Ato M, Kelsoe G, Takahashi Y. Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies. Nat Commun. 2019;10:3883. PMCID: PMC6713747.

            Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe G. Self-tolerance curtails the B cell repertoire to microbial epitopes. JCI Insight. 2019;4. PMCID: PMC6542615.

            Lee J, Paparoditis P, Horton AP, Fruhwirth A, McDaniel JR, Jung J, Boutz DR, Hussein DA, Tanno Y, Pappas L, Ippolito GC, Corti D, Lanzavecchia A, Georgiou G. Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations. Cell Host Microbe. 2019; 25:367-76. PMCID: PMC6417944.

            Bajic G, van der Poel CE, Kuraoka M, Schmidt AG, Carroll MC, Kelsoe G, Harrison SC. Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies. Sci Rep. 2019; 9:3492. PMCID: PMC6401307.

 

2018

            Ferdman J, Palladino G, Liao HX, Moody MA, Kepler TB, Del Giudice G, Dormitzer PR, Harrison SC, Settembre EC, Suphaphiphat P. Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59(R)-adjuvanted pandemic 2009 H1N1 vaccine. Vaccine. 2018;36:5325-32. PMCID: PMC6521956.

            McCarthy KR, Watanabe A, Kuraoka M, Do KT, McGee CE, Sempowski GD, Kepler TB, Schmidt AG, Kelsoe G, Harrison SC. Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity. 2018;48:174-84. PMCID: PMC5810956.

            Finney J, Yeh CH, Kelsoe G, Kuraoka M. Germinal center responses to complex antigens. Immunol Rev. 2018;284:42-50. PMCID: PMC6023402.

 

2016

            Raymond DD, Stewart SM, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre, E, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, Kepler TP, Haynes BF, Moody MA, Liao, H-X, Schmidt AG, Harrison SC. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nature Medicine 2016;22:1465-1469.  PMCID: PMC5485662.

            Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, Murrin EM, Chrysostomou C, Hoi KH, Tsybovsky Y, Thomas, PV, Druz A, Zhang B, Zhang Y, Wang L, Kong WP, Park D, Popova LI, Dekker CL, David MM, Carter CE, Ross TM, Ellingont AD, Wilson PC, Marcotte EM, Mascola JR, Ippolito GC, Krammer F, Quake SR, Kwong PD, Georgiou G. Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nature Medicine 2016;22:1456-1464. PMCID:  PMC5301914.

            Kuraoka M, Schmidt AG, Nojima T, Feng F. Watanabe A, Kitamura D. Harrison SC, Kepler TB, Kelsoe G.  B-cell selection in germinal centers elicited by complex antigens. Immunity 2016;44: 43-54. PMCID: PMC4794380.

 

 2015

            Schmidt, AG, Do TK, McCarthy KR, Kepler TB, Liao H-X, Moody MA, Haynes BF, Harrison SC,  Immunogenic stimulus for germline precursors of influenza-specific antibodies. Cell Reports 2015;13:2842-50. PMCID:  PMC4698027.

            Schmidt AG, Therkelsen MD, Stewart, S, Kepler TB, Liao, X-H, Moody MA, Haynes BF, Harrison SC. Viral Receptor-Binding Site Antibodies with Diverse Germline Origins.  Cell 2015; 161:1026-1034. PMCID:  PMC4441819.

            Xu H, Schmidt, AG, O'Donnell T, Therkelsen MD, T Kepler TB, Moody MA, Haynes BF, Liao, H-X, Harrison SC, Shaw DE.  Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.  Proteins 2015;83:771–780. PMCID: PMC4368477.

 

2013

            Schmidt AG, Xu H, Khan AR, O’Donnell T, Khurana S, King LR, Manischewitz J, Golding H, Suphaphiphat P, Carfi A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R, Moody MA, Haynes BF, Liao H-X, Shaw DE, Harrison SC.  Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.  Proc Natl Acad Sci USA. 2013; 110:264–269. PMCID: PMC3538208.

 

2012

            Haynes, BF, Kelsoe, G, Harrison SC, Kepler, TB. B cell lineage immunogen design in vaccine development with HIV as a case study.  Nature Biotechnol. 2012;30:423-33.  PMCID: PMC3512202.

 

2011

            Whittle JRR, Zhang R, Khurana S, King LR, Manischewitz J, Golding H, Dormitzer PR, Haynes BF, Walter EB, Moody MA, Kepler TB, Liao H-X, Harrison SC. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.

Proc Natl Acad Sci USA 2011;108:14216–14221. PMCID: PMC3161572.

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