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Finney J, Watanabe A, Kelsoe G, Kuraoka M. Minding the gap: the impact of B-cell tolerance on the microbial antibody repertoire. Immunol Rev. 2019 November; 292(1): 24–36. doi:10.1111/imr.12805

Lee J, Paparoditis P, Horton AP, Frühwirth A, McDaniel JR, Jung J, Boutz DR, Hussein DA, Tanno Y, Pappas L, Ippolito GC, Corti D, Lanzavecchia A, Georgiou G. Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations. Cell Host Microbe. 2019 Mar 13;25(3):367-376.e5. doi: 10.1016/j.chom.2019.01.010

Bajic G, Maron MJ, Caradonna TM, Tian M, Mermelstein A, Fera D, Kelsoe G, Kuraoka M, Schmidt AG. Structure-Guided Molecular Grafting of a Complex Broadly Neutralizing Viral Epitope. ACS Infectious Diseases . 2020 Apr 20. DOI: 10.1021/acsinfecdis.0c00008 PMID: 32267676

Lee J, Paparoditis P, Horton AP, Frühwirth A, McDaniel JR, Jung J, Boutz DR, Hussein DA, Tanno Y, Pappas L, Ippolito GC, Corti D, Lanzavecchia A, Georgiou G. Persistent antibody clonotypes dominate the serum Response to influenza over multiple years and repeated vaccinations. Cell Host Microbe. 2019 Mar 13;25(3):367-376.e5. doi: 10.1016/j.chom.2019.01.010. Epub 2019 Feb 19 (2019) PMCID: PMC6417944

McCarthy, K.R., Raymond, D.D., Do, K.T., Schmidt, A.G., Harrison, S.C.  Affinity maturation in a human humoral response to influenza hemagglutinin.  PNAS 116 (52):  26745-51 (2019)

Bajic, G., Maron, M.J., Adachi, Y., Onodera, T., McCarthy, K.R., McGee, C.E., Sempowski, G.D., Takahashi, Y., Kelsoe, G., Kuraoka, M., Schmidt, A.G.  Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.  Cell Host & Microbe. May 14; 25:  1- 9 (2019) PMID: PMC6401307

Watanabe, A., McCarthy, K.R., Kuraoka, M., Schmidt, A.G., Adachi, Y., Onodera, T., Tonouchi, K., Caradonna, T.M., Bajic, G., Song, S., McGee, C.E., Sempowski, G.D., Feng, F., Urick, P., Kepler, T.B., Takahashi, Y., Harrison, S.C., Kelsoe, G.  Antibodies to a conserved influenza head iterface epitope protect by an IgG subtype-dependent mechanism.  Cell 177:  1124-1135 (2019)

Bajic G, van der Poel CE, Kuraoka M, Schmidt AG, Carroll MC, Kelsoe G, Harrison SC. Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies. Scientific Reports. 2019 Mar 5;9(1):3492. doi: 10.1038/s41598-019-40175-8. PMID: 30837606 

Ferdman, J., Palladino, G., Liao, H-X., Moody, M.A., Kepler, T.B., Del Giudice, G., Dormitzer, P.R., Harrison, S.C., Settembre, E.C., Suphaphiphat, P., Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59-adjuvanted pandemic 2009 H1N1 vaccine. J. Vaccine 10.1016: 8 (2018).

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Schmidt, A.G., Xu, H., Khan, A.R., O’Donnell, T., Khurana, S., King, L.R., Manischewitz, J., Golding, H., Suphaphiphat, P., Carfi, A., Settembre, E.C., Dormitzer, P.R., Kepler, T.B., Zhang, R., Moody, M.A., Haynes, B.F., Liao, H-X., Shaw, D.E., Harrison, S.C.  Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.  Proc Natl Acad Sci U S A.  110(1): 264–269 (2013). PMCID: PMC3538208

Xu, H., Schmidt, A.G., O’Donnell, T., Therkelsen, M.D., Kepler, T.B., Moody, M.A., Haynes, B.F., Liao, H-X., Harrison, S.C., Shaw, D.E.  Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.  Proteins  83(4): 771–780 (2015). PMCID: PMC4368477

Jackson, K.J.L., Liu, Y., Roskin, K.M., Glanville, J., Hoh, R.A., Seo, K., Marshall, E.L., Gurley, T.C., Moody, M.A., Haynes, B.F., Walter, E.B., Liao, H-X., Albrecht, R.A., García-Sastre, A., Chaparro-Riggers, J., Rajpal, A., Pons, J., Simen, B.B., Hanczaruk, B., Dekker, C.L., Laserson, J.,  Koller, D., Davis, M.M., Fire, A.Z., Boyd, S.D.  Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements.  Cell Host Microbe 16(1): 105–114 (2014). PMCID: PMC4158033


Schmidt, A.G., Therkelsen, M.D., Stewart, S., Kepler, T.B., Liao, X-H., Moody, M.A., Haynes, B.F., Harrison, S.C.  Viral Receptor-Binding Site Antibodies with Diverse Germline Origins.  Cell 161:  1026-1034 (2015)  PMCID:  PMC4441819.


Schmidt, A.G., Do, T.K., McCarthy, K.R., Kepler, T.B., Liao,H-X., Moody, M.A., Haynes, B.F., Harrison,S.C.,  Immunogenic stimulus for germline precursors of influenza-specific antibodies. Cell Reports 9(2015) 13:  2842-50 PMCID:  PMC4698027.


Kuraoka, M., Schmidt A.G., Nojima T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S.C., Kepler T.B., and Kelsoe G.  B-cell selection in germinal centers elicited by complex antigens. Immunity, 44, 43-54 (2016). PMCID: PMC4794380

Raymond, D.D., Stewart, S.M., Lee, J., Ferdman, J., Bajic, G., Do, K.T., Ernandes, M.J., Suphaphiphat, P., Settembre, E., Dormitzer, P.R., Del Giudice.G., Finco, O., Kang, T.H., Ippolito, G.C., Georgiou, G., Kepler, T.P., Haynes, B.F., Moody, M.A., Liao, H-X., Schmidt, A.G., Harrison, S.C. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nature Medicine 10.1038: 1-7 (2016). PMCID: PMC5485662

Liu, Y.,  Pan, J.,  Jenni, S.,  Raymond, D.D., Caradonna, T., Do, K.T., Schmidt, A.G., Harrison, S.C., Grigorieff, N.,  CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface.  Journal of Molecular Biology 429:  1829-1839  (2017).  PMCID:  PMC5535819


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Raymond, D.D., Bajic, G., Ferdman, J., Suphaphiphat, P., Settembre, E., Moody, M.A., Schmidt, A.G., Harrison, S.C. Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. PNAS 115: 168-173 (2018). PMCID:  PMC5776812

McCarthy, K.R., Watanabe, A., Kuraoka, M., Do., K.T., McGee, C.E., Sempowski, G.D., Kepler, T.B., Schmidt, A.G., Kelsoe, G., Harrison,S.C. Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity 48: 174-184 (2018).  PMCID:  PMC5177464