2026
Ge X, Stoner MR, Weiner JA, Parigela SS, Balderas Hernandez ME, Taher N, Lee J, Ackerman ME. IgA binding characteristics of golden hamster and ferret Fcα receptors. J Immunol. 2026;215(8). PMCID: PMC13548764.
2025
Maurer DP, Vu M, Schmidt AG. Antigenic drift expands influenza viral escape pathways from recalled humoral immunity. Immunity. 2025;58(3):716-727.e6. PMCID: PMC11906258.
Feldman J, Ferreira Ramos AS, Vu M, Maurer D, Rosado VC, Lingwood D, Bajic G, Schmidt AG. Human naive B cells recognize prepandemic influenza virus hemagglutinins. Sci Immunol. 2025;10(103):eado9572. PMCID: PMC12117473.
Simmons HC, Finney J, et al, Kelsoe G, Takahashi Y, McCarthy KR. A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface. mBio. 2025;e0089225. PMID: 40391889.
Finney J, Kuraoka M, Song S, Watanabe A, Liang X, Liao D, Moody MA, Walter EB, Harrison SC, Kelsoe G. Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases. Vaccine. 2025;56:127157. PMCID: PMC12086040.
Maurer DP, Vu M, Ferreira Ramos AS, Dugan HL, Kahlife P, Geoghegan JC, Walker LM, Bajic G, Schmidt AG. Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies. Sci Adv. 2025;11:eadu9140. PMCID: PMC12017299.
2024
Ray R, et al, Schmidt AG, Batista FD, Lingwood D. Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity. 2024;57:1141-1159.e11. PMCID: PMC11096021.
Finney J, Moseman AP, Kong S, Watanabe A, Walsh RM Jr, Kuraoka M, Kotaki R, Moseman EA, McCarthy KR, Liao D, Liang X, Nie X, Lavidor O, Abbott R, Harrison SC, Kelsoe G. Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin. Proc Natl Acad Sci U S A. 2024;121:e2316964120. PMCID: PMC10769852.
2023
Simmons HC, Watanabe A, Oguin TH, Van Italie ES, Wiehe KJ, Sempowski GD, Kuraoka M, Kelsoe G, McCarthy KR. A new class of antibodies that overcomes a steric barrier to cross-group neutralization of influenza viruses. PLoS Biol. 2023;21:e3002415. PMCID: PMC10734940.
Yang L, Caradonna TM, Schmidt AG, Chakraborty AK. Mechanisms that promote the evolution of cross-reactive antibodies upon vaccination with designed influenza immunogens. Cell Rep. 2023;42:112160. PMID: 36867533. PMCID: PMC10184763.
Sawant S, Gurley SA, Overman RG, Sharak A, Mudrak SV, Oguin T 3rd, Sempowski GD, Sarzotti-Kelsoe M, Walter EB, Xie H, Pasetti M, Moody MA, Tomaras GT. H3N2 influenza hemagglutination inhibition method qualification with data driven statistical methods for human clinical trials. Front Immunol. 2023;14:1155880. PMID: 37090729. PMCID: PMC10117676.
Phillips AM, Maurer DP, Brooks C, Dupic T, Schmidt AG, Desai MM. Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody. eLife. 2023;12:e83628. PMCID: PMC9995116.
2022
Caradonna TM, Ronsard L, Yousif AS, Windsor IW, Hecht R, Bracamonte-Moreno T, Roffler A, Maron MJ, Maurer DP, Feldman J, Marchiori E, Barnes R, Rohrer D, Lonberg N, Oguin TH, Sempowski GD, Kepler TB, Kuraoka M, Lingwood D, Schmidt AG. An epitope-enriched immunogen expands responses to a conserved viral site. Cell Rep. 2022;41:111628. PMCID: PMC9883670.
Kuraoka M, Curtis NC, Watanabe A, Tanno H, Shin S, Ye K, Macdonald E, Lavidor O, Kong S, Von Holle T, Windsor I, Ippolito G, Georgiou G, Walter EB, Kelsoe G, Harrison SC, Moody MA, Bajic G, Lee J. Infant antibody repertoires during the first two years of influenza vaccination. mBio. 2022;13(6):e0254622. PMCID: PMC9765176.
Kuraoka M, Yeh CH, Bajic G, Kotari R, Song S, Windsor I, Harrison SC, Kelsoe G. Recall of B cell memory depends on relative locations of prime and boost immunization. Sci Immunol. 2022;7:eabn5311. PMCID: PMC9169233.
Yeh CH, Finney J, Okada T, Kurosaki T, Kelsoe G. Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells. Immunity. 2022;55(2):272-289.e7. PMCID: PMC8842852.
2021
Caradonna TM, Schmidt AG. Protein engineering strategies for rational immunogen design. NPJ Vaccines. 2021;6:154. PMCID: PMC8683408.
Song S, Manook M, Kwun J, Jackson AM, Knechtle SJ, Kelsoe G. A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines. Commun Biol. 2021;4:1338. PMCID: PMC8617053.
Bajic G, Harrison SC. Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses. ACS Infect Dis. 2021;7:1-5. PMCID: PMC8276581.
McCarthy KR, Lee J, Watanabe A, Kuraoka M, Robinson-McCarthy LR, Georgiou G, Kelsoe G, Harrison SC. A prevalent focused human antibody response to the influenza virus hemagglutinin head interface. mBio. 2021;12:e0114421. PMCID: PMC8262862.
McCarthy KR, Von Holle TA, Sutherland LL, Oguin TH 3rd, Sempowski GD, Harrison SC, Moody MA. Differential immune imprinting by influenza virus vaccination and infection in non-human primates. Proc Natl Acad Sci U S A. 2021;118:e2026752118. PMCID: PMC8201799.
2020
Bajic G, Maron MJ, Caradonna TM, Tian M, Mermelstein A, Fera D, Kelsoe G, Kuraoka M, Schmidt AG. Structure-guided molecular grafting of a complex broadly neutralizing viral epitope. ACS Infect Dis. 2020;6:1182-1191. PMCID: PMC7291361.
2019
McCarthy KR, Raymond DD, Do KT, Schmidt AG, Harrison SC. Affinity maturation in a human humoral response to influenza hemagglutinin. Proc Natl Acad Sci U S A. 2019;116:26745-26751. PMCID: PMC6936356.
Finney J, Watanabe A, Kelsoe G, Kuraoka M. Minding the gap: the impact of B-cell tolerance on the microbial antibody repertoire. Immunol Rev. 2019;292:24-36. PMCID: PMC6935408.
Onodera T, Hashi K, Shukla RK, Miki M, Takai-Todaka R, Fujimoto A, Kuraoka M, Miyoshi T, Kobayashi K, Hasegawa H, Ato M, Kelsoe G, Katayama K, Takahashi Y. Immune-focusing properties of virus-like particles improve protective IgA responses. J Immunol. 2019;203:3282-3292. PMCID: PMC6900486.
Watanabe A, McCarthy KR, Kuraoka M, Schmidt AG, Adachi Y, Onodera T, Tonouchi K, Caradonna TM, Bajic G, Song S, McGee CE, Sempowski GD, Feng F, Urick P, Kepler TB, Takahashi Y, Harrison SC, Kelsoe G. Antibodies to a conserved influenza head interface epitope protect by an IgG subtype-dependent mechanism. Cell. 2019;177:1124-1135.e16. PMCID: PMC6825805.
Bajic G, Maron MJ, Adachi Y, Onodera T, McCarthy KR, McGee CE, Sempowski GD, Takahashi Y, Kelsoe G, Kuraoka M, Schmidt AG. Influenza antigen engineering focuses immune responses to a subdominant but broadly protective viral epitope. Cell Host Microbe. 2019;25:827-835.e6. PMCID: PMC6748655.
Lee J, Paparoditis P, Horton AP, Fruhwirth A, McDaniel JR, Jung J, Boutz DR, Hussein DA, Tanno Y, Pappas L, Ippolito GC, Corti D, Lanzavecchia A, Georgiou G. Persistent antibody clonotypes dominate the serum response to influenza over multiple years and repeated vaccinations. Cell Host Microbe. 2019;25:367-376.e5. PMCID: PMC6417944.
Bajic G, van der Poel CE, Kuraoka M, Schmidt AG, Carroll MC, Kelsoe G, Harrison SC. Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies. Sci Rep. 2019;9:3492. PMCID: PMC6401307.
2018
Ferdman J, Palladino G, Liao HX, Moody MA, Kepler TB, Del Giudice G, Dormitzer PR, Harrison SC, Settembre EC, Suphaphiphat P. Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59(R)-adjuvanted pandemic 2009 H1N1 vaccine. Vaccine. 2018;36:5325-5332. PMCID: PMC6521956.
McCarthy KR, Watanabe A, Kuraoka M, Do KT, McGee CE, Sempowski GD, Kepler TB, Schmidt AG, Kelsoe G, Harrison SC. Memory B cells that cross-react with group 1 and group 2 influenza A viruses are abundant in adult human repertoires. Immunity. 2018;48:174-184.e9. PMCID: PMC5810956.
Finney J, Yeh CH, Kelsoe G, Kuraoka M. Germinal center responses to complex antigens. Immunol Rev. 2018;284:42-50. PMCID: PMC6023402.
2016
Raymond DD, Stewart SM, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre E, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, Kepler TP, Haynes BF, Moody MA, Liao HX, Schmidt AG, Harrison SC. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med. 2016;22:1465-1469. PMCID: PMC5485662.
Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, Murrin EM, Chrysostomou C, Hoi KH, Tsybovsky Y, Thomas PV, Druz A, Zhang B, Zhang Y, Wang L, Kong WP, Park D, Popova LI, Dekker CL, David MM, Carter CE, Ross TM, Ellington AD, Wilson PC, Marcotte EM, Mascola JR, Ippolito GC, Krammer F, Quake SR, Kwong PD, Georgiou G. Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nat Med. 2016;22:1456-1464. PMCID: PMC5301914.
Kuraoka M, Schmidt AG, Nojima T, Feng F, Watanabe A, Kitamura D, Harrison SC, Kepler TB, Kelsoe G. Complex antigens elicit diverse patterns of clonal selection in germinal centers. Immunity. 2016;44:542-552. PMCID: PMC4794380.
2015
Schmidt AG, Do TK, McCarthy KR, Kepler TB, Liao HX, Moody MA, Haynes BF, Harrison SC. Immunogenic stimulus for germline precursors of antibodies that engage the influenza hemagglutinin receptor-binding site. Cell Rep. 2015;13:2842-2850. PMCID: PMC4698027.
Schmidt AG, Therkelsen MD, Stewart S, Kepler TB, Liao HX, Moody MA, Haynes BF, Harrison SC. Viral receptor-binding site antibodies with diverse germline origins. Cell. 2015;161:1026-1034. PMCID: PMC4441819.
Xu H, Schmidt AG, O'Donnell T, Therkelsen MD, Kepler TB, Moody MA, Haynes BF, Liao HX, Harrison SC, Shaw DE. Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage. Proteins. 2015;83:771-780. PMCID: PMC4368477.
2013
Schmidt AG, Xu H, Khan AR, O'Donnell T, Khurana S, King LR, Manischewitz J, Golding H, Suphaphiphat P, Carfi A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R, Moody MA, Haynes BF, Liao HX, Shaw DE, Harrison SC. Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci U S A. 2013;110:264-269. PMCID: PMC3538208.
2012
Haynes BF, Kelsoe G, Harrison SC, Kepler TB. B cell lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol. 2012;30:423-433. PMCID: PMC3512202.
2011
Whittle JRR, Zhang R, Khurana S, King LR, Manischewitz J, Golding H, Dormitzer PR, Haynes BF, Walter EB, Moody MA, Kepler TB, Liao HX, Harrison SC. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proc Natl Acad Sci U S A. 2011;108:14216-14221. PMCID: PMC3161572.