NATIONAL INSTITUTES OF HEALTH P01AI089618

© 2018 PRESIDENT AND FELLOWS OF HARVARD COLLEGE

KEY PUBLICATIONS

Bajic, G., Maron, M.J., Adachi, Y., Onodera, T., McCarthy, K.R., McGee, C.E., Sempowski, G.D., Takahashi, Y., Kelsoe, G., Kuraoka, M., Schmidt, A.G.  Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.  Cell Host & Microbe. May 14; 25:  1- 9 (2019) PMID: PMC6401307

 

Watanabe, A., McCarthy, K.R., Kuraoka, M., Schmidt, A.G., Adachi, Y., Onodera, T., Tonouchi, K., Caradonna, T.M., Bajic, G., Song, S., McGee, C.E., Sempowski, G.D., Feng, F., Urick, P., Kepler, T.B., Takahashi, Y., Harrison, S.C., Kelsoe, G.  Antibodies to a conserved influenza head iterface epitope protect by an IgG subtype-dependent mechanism.  Cell 177:  1124-1135 (2019)

 

Bajic G, van der Poel CE, Kuraoka M, Schmidt AG, Carroll MC, Kelsoe G, Harrison SC. Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies. Scientific Reports. 2019 Mar 5;9(1):3492. doi: 10.1038/s41598-019-40175-8. PMID: 30837606 

 

Ferdman, J., Palladino, G., Liao, H-X., Moody, M.A., Kepler, T.B., Del Giudice, G., Dormitzer, P.R., Harrison, S.C., Settembre, E.C., Suphaphiphat, P., Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59-adjuvanted pandemic 2009 H1N1 vaccine. J. Vaccine 10.1016: 8 (2018).

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Whittle, J.R.R., Zhang, R., Khurana, S., King, L.R., Manischewitz, J., Golding, H., Dormitzer, P.R., Haynes, B.F., Walter, E.B., Moody, M.A.,  Kepler, T.B., Liao, H-X.,  Harrison, S.C. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutininProc Natl Acad Sci U S A.  August 23; 108(34): 14216–14221 (2011). PMCID: PMC3161572

 

Schmidt, A.G., Xu, H., Khan, A.R., O’Donnell, T., Khurana, S., King, L.R., Manischewitz, J., Golding, H., Suphaphiphat, P., Carfi, A., Settembre, E.C., Dormitzer, P.R., Kepler, T.B., Zhang, R., Moody, M.A., Haynes, B.F., Liao, H-X., Shaw, D.E., Harrison, S.C.  Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.  Proc Natl Acad Sci U S A.  110(1): 264–269 (2013). PMCID: PMC3538208

 

Xu, H., Schmidt, A.G., O’Donnell, T., Therkelsen, M.D., Kepler, T.B., Moody, M.A., Haynes, B.F., Liao, H-X., Harrison, S.C., Shaw, D.E.  Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.  Proteins  83(4): 771–780 (2015). PMCID: PMC4368477

 

Jackson, K.J.L., Liu, Y., Roskin, K.M., Glanville, J., Hoh, R.A., Seo, K., Marshall, E.L., Gurley, T.C., Moody, M.A., Haynes, B.F., Walter, E.B., Liao, H-X., Albrecht, R.A., García-Sastre, A., Chaparro-Riggers, J., Rajpal, A., Pons, J., Simen, B.B., Hanczaruk, B., Dekker, C.L., Laserson, J.,  Koller, D., Davis, M.M., Fire, A.Z., Boyd, S.D.  Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements.  Cell Host Microbe 16(1): 105–114 (2014). PMCID: PMC4158033

 

Schmidt, A.G., Therkelsen, M.D., Stewart, S., Kepler, T.B., Liao, X-H., Moody, M.A., Haynes, B.F., Harrison, S.C.  Viral Receptor-Binding Site Antibodies with Diverse Germline Origins.  Cell 161:  1026-1034 (2015)  PMCID:  PMC4441819.

 

Schmidt, A.G., Do, T.K., McCarthy, K.R., Kepler, T.B., Liao,H-X., Moody, M.A., Haynes, B.F., Harrison,S.C.,  Immunogenic stimulus for germline precursors of influenza-specific antibodies. Cell Reports 9(2015) 13:  2842-50 PMCID:  PMC4698027.

 

Kuraoka, M., Schmidt A.G., Nojima T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S.C., Kepler T.B., and Kelsoe G.  B-cell selection in germinal centers elicited by complex antigens. Immunity, 44, 43-54 (2016). PMCID: PMC4794380

 

Raymond, D.D., Stewart, S.M., Lee, J., Ferdman, J., Bajic, G., Do, K.T., Ernandes, M.J., Suphaphiphat, P., Settembre, E., Dormitzer, P.R., Del Giudice.G., Finco, O., Kang, T.H., Ippolito, G.C., Georgiou, G., Kepler, T.P., Haynes, B.F., Moody, M.A., Liao, H-X., Schmidt, A.G., Harrison, S.C. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nature Medicine 10.1038: 1-7 (2016). PMCID: PMC5485662
 

Liu, Y.,  Pan, J.,  Jenni, S.,  Raymond, D.D., Caradonna, T., Do, K.T., Schmidt, A.G., Harrison, S.C., Grigorieff, N.,  CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface.  Journal of Molecular Biology 429:  1829-1839  (2017).  PMCID:  PMC5535819

 

Lee J., Boutz DRChromikova V, Joyce MG, Vollmers CLeung KHorton APDeKosky BJLee CHLavinder JJMurrin EMChrysostomou CHoi KHTsybovsky YThomas PVDruz AZhang BZhang YWang LKong WPPark DPopova LIDekker CLDavis MMCarter CERoss TM,Ellington ADWilson PCMarcotte EMMascola JRIppolito GCKrammer FQuake SRKwong PDGeorgiou G..  Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.  Nat Med. Dec;22(12):1456-1464. doi: 10.1038/nm.4224. Epub 2016 Nov 7. (2016) PMCID: PMC5301914.
 

Raymond, D.D., Bajic, G., Ferdman, J., Suphaphiphat, P., Settembre, E., Moody, M.A., Schmidt, A.G., Harrison, S.C. Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. PNAS 115: 168-173 (2018). PMCID:  PMC5776812

 

McCarthy, K.R., Watanabe, A., Kuraoka, M., Do., K.T., McGee, C.E., Sempowski, G.D., Kepler, T.B., Schmidt, A.G., Kelsoe, G., Harrison,S.C. Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity 48: 174-184 (2018).  PMCID:  PMC5177464