Structure-Function Analysis of Influenza-Virus Infection -
and Vaccine-Induced B-Cell Repertoires
Studies of the immune response to influenza virus seek to discover vaccination strategies that confer long-lasting immunity in the face of rapid antigenic variation of circulating subtypes and of potential introduction of new subtypes into the human population. Moreover, identification of human antibodies that neutralize a broad range of influenza isolates and structural characterization of their epitopes have raised the possibility of "universal" influenza vaccines, to replace the annually updated immunogens in current seasonal immunizations. The research in this Program will contribute to design of vaccines that yield more predictable and durable immunity.
The key question is: if we know the kind of antibody we would like to elicit, how do we learn enough about the immune response to create the right immunogen and the right immunization regimen?